Francisella-FUGUE
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Contents |
Overview
The goal is to identify proteins coded for in the genome of Francisella Tularensis that are involved in infection and host specific activities.
One possible route by which bacteria can interact with a host is through proteins that mimic those of the host. This allows the bacteria to gain control of targeted host processes, such as turing off or evading the immune system, increasing local food supplies, and transportation into cells or between organs in a host.
By identifying proteins that have similar structure in a pathogen and a host but do not share high sequence similarity, one can select for coevolved proteins that have been developed for use by a pathogen to target a certain host species. The software program suite FUGUE uses structural elements to annotate a protein profile and then align it to a sequence profile. This is the core of the current scheme to search the genome of Francisella for coevolved proteins.
People
Current
Stuart R. Jefferys (User:Srj)
Collaborators
Jeff Frelinger, Ph.D
