Current events

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==Seminars of Interest== ==Seminars of Interest==
-Department of Microbiology & Immunology, +'''The Department of Microbiology and Immunology
-The University of North Carolina at Chapel Hill, +School of Medicine
-Chapel Hill, North Carolina +University of North Carolina at Chapel Hill'''
-D I S S E R T A T I O N S E M I N A R+Fall 2006 Seminar Schedule
-Timothy P. Moran+''All seminars are held on Thursday at 3:30 p.m. at the Lineberger Comprehensive Cancer Center in the Plaza Level Conference Room unless otherwise noted.''
-''“Characterization of Dendritic Cells Transduced with Venezuelan Equine Encephalitis Virus Replicon Particles as Therapeutic Cancer Vaccines”'' 
-Wednesday, August 16, 2006, 3:00 p.m., Plaza Level Conference Room, Lineberger Comprehensive Cancer Center+'''September 7''' James Brown, Ph.D., Associate Professor of Microbiology, NC State University, "Ribonuclease P: A relic of the RNA World?"
 +Host: Bob Bourret (bourret@med.unc.edu)
 +
 +'''September 21''' - Bioinformatics Rm. 1131
 +Max D. Cooper, M.D., Professor of Medicine, Pediatrics, Pathology and Microbiology, Univ. of Alabama at Birmingham, HHMI, "Evolution of Adaptive Immunity." NOTE LOCATION: 1131 Bioinformatics Bldg.
 +Host: Jeff Frelinger (jfrelin@med.unc.edu)
 +
 +'''September 28'''
 +John F. Alderete, Ph.D., Professor of Microbiology & Immunology, Univ. of Texas Health Science Center at San Antonio, "Trichomonas vaginalis Induced Genes, Membrane Remodeling and Diagnostics."
 +Host: Marcia Hobbs (mmhobbs@med.unc.edu)
-Dissertation Advisors: Jonathan Serody and Robert Johnston+'''October 19''' David Markovitz, M.D., Professor of Internal Medicine, University of Michigan, "Adventures with the Exotic DEK Protein."
- +Host: Joseph Pagano (966-5907)
-Presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy+
- +'''Tuesday, October 24 at 2:00''' Special Seminar-note day & time
-ABSTRACT: TIMOTHY P. MORAN: Characterization of Dendritic Cells Transduced with Venezuelan Equine Encephalitis Virus Replicon Particles as Therapeutic Cancer Vaccines (Under the direction of Jonathan S. Serody and Robert E. Johnston)+Philippe J. Sansonetti, M.D., Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, "Rupture, invasion and inflammatory destruction of the intestinal epithelium by Shigella: the Yin and the Yang of innate immunity."
- +Host: Miriam Braunstein (braunste@med.unc.edu)
-Cancer vaccines seek to harness the specificity of T and B lymphocytes for reduction of tumor burden, as well as prevention of recurrent disease by establishing immunological memory. Because of their ability to initiate adaptive immune responses, dendritic cells (DCs) presenting tumor antigens have frequently been used as cancer vaccines. Unfortunately, induction of therapeutic responses in cancer patients has been sporadic, suggesting that current DC vaccines are unable to surmount tolerance against tumor antigens. The transduction of DCs with recombinant viral vectors may be a viable strategy for augmenting the ability of DC vaccines to break tolerance, as this approach can be used to efficiently deliver tumor antigens to DCs in the context of an immunostimulatory viral infection. Therefore, we have investigated the potential of DCs transduced with Venezuelan equine encephalitis virus replicon particles (VRPs) as cancer vaccines. VRPs could efficiently transduce human and murine immature DCs ex vivo, leading to high-level transgene expression, DC maturation, secretion of proinflammatory cytokines and efficient presentation of VRP-encoded antigens to T cells. VRP-transduced DCs (VRP-DCs) expressing a truncated neu oncoprotein stimulated neu-specific T cell and antibody responses and induced regression of established tumors in nontolerant mice. In contrast, VRP-DCs failed to induce robust antitumor responses in mice tolerant to neu, and were likewise unable to inhibit tumor growth. Depletion of CD4+CD25+ regulatory T cells (Treg) improved the effectiveness of VRP-DC vaccines in tolerant mice, demonstrating that VRP-DCs alone were unable to overcome Treg activity. Furthermore, provision of tolerant mice with neu-specific T cells from nontolerant mice did not augment vaccine efficacy, indicating that tolerogenic mechanisms are dominant over effector T cell activity. These results demonstrate that while highly immunogenic, virally-activated DCs cannot break tolerance against self/tumor antigens. Moreover, these findings imply that potent DC vaccines alone are unlikely to induce therapeutic antitumor immunity unless additional measures are undertaken to inhibit immunoregulatory mechanisms.+
- +'''October 26''' Michael Hudson, Ph.D., Professor and Chair, Department of Biology, UNC-Charlotte, "Staphylococcus aureus-Induced Bone Disease: Do Osteoblasts Contribute to Pathology?"
-----+Host: Matt Wolfgang (Matt_Wolfgang@med.unc.edu)
-DISSERTATION SEMINAR+
- +'''November 2''' Simon Frost, Ph.D., Univ. of CA, San Diego, TBA.
-Will McRoy+Co-sponsored by CFAR.
- +Host: Ron Swanstrom (risunc@med.unc.edu)
-''"Determinants of Mouse Hepatitis Virus Host Range Expansion"''+
- +'''November 9''' Salam Ibrahim, Ph.D., Assistant Professor, Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, TBA.
-'''Friday, June 30, 2006, 1:00 p.m., Blue Cross Blue Shield Auditorium, Michael Hooker Research Center'''+Host: Morgan Giddings (giddings@unc.edu)
- +
-Directions: Enter the School of Public Health through the main glass doors off Columbia (the only ones open due to construction) as if going to the snack bar and go down the big stair case to the basement.+'''November 16''' Michael Laub, Ph.D., Fellow, Harvard University, TBA.
- +Host: Bob Bourret (bourret@med.unc.edu)
-Dissertation Advisor: Ralph Baric+
- +'''November 30''' Etty (Tika) Benveniste, Ph.D., Professor and Chair, Univ. of Alabama at Birmingham, "Regulation of CD40 Expression in Macrophages/Microglia: Inhibition by SOCS-1 and SOCS-3."
-Presented in partial fulfillment of the requirements for the degree of Doctor of Philosophy+Host: Jenny Ting (jenny_ting@med.unc.edu)
-----+
-DISSERTATION SEMINAR+For more seminar information visit [http://microimm.med.unc.edu/calendar.aspx http://microimm.med.unc.edu/calendar.aspx]
- +
-Mark A. Wallet+
- +
-''"MerTK Mediates Immune Homeostasis: Effects upon Dendritic Cell Function and Type 1 Diabetes"''+
- +
-'''Thursday, July 6, 2006, 1:00 p.m., 1131 Bioinformatics Building'''+
- +
-Dissertation Advisor: Roland Tisch+
==Conferences of Interest== ==Conferences of Interest==

Revision as of 16:50, 24 August 2006

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Contents

Lab Meetings

Lab Meetings are on Fridays at 1:30 in room 802 Mary Ellen Jones Building unless otherwise posted.
The person that presented in the previous week is responsible for bringing snacks and munchies for the current week, lest they be subject to a Public Shaming! Woe betide thee that forgetteth the munchies!

Seminars of Interest

The Department of Microbiology and Immunology School of Medicine University of North Carolina at Chapel Hill

Fall 2006 Seminar Schedule

All seminars are held on Thursday at 3:30 p.m. at the Lineberger Comprehensive Cancer Center in the Plaza Level Conference Room unless otherwise noted.


September 7 James Brown, Ph.D., Associate Professor of Microbiology, NC State University, "Ribonuclease P: A relic of the RNA World?" Host: Bob Bourret (bourret@med.unc.edu)

September 21 - Bioinformatics Rm. 1131 Max D. Cooper, M.D., Professor of Medicine, Pediatrics, Pathology and Microbiology, Univ. of Alabama at Birmingham, HHMI, "Evolution of Adaptive Immunity." NOTE LOCATION: 1131 Bioinformatics Bldg. Host: Jeff Frelinger (jfrelin@med.unc.edu)

September 28 John F. Alderete, Ph.D., Professor of Microbiology & Immunology, Univ. of Texas Health Science Center at San Antonio, "Trichomonas vaginalis Induced Genes, Membrane Remodeling and Diagnostics." Host: Marcia Hobbs (mmhobbs@med.unc.edu)

October 19 David Markovitz, M.D., Professor of Internal Medicine, University of Michigan, "Adventures with the Exotic DEK Protein." Host: Joseph Pagano (966-5907)

Tuesday, October 24 at 2:00 Special Seminar-note day & time Philippe J. Sansonetti, M.D., Unité de Pathogénie Microbienne Moléculaire, Institut Pasteur, "Rupture, invasion and inflammatory destruction of the intestinal epithelium by Shigella: the Yin and the Yang of innate immunity." Host: Miriam Braunstein (braunste@med.unc.edu)

October 26 Michael Hudson, Ph.D., Professor and Chair, Department of Biology, UNC-Charlotte, "Staphylococcus aureus-Induced Bone Disease: Do Osteoblasts Contribute to Pathology?" Host: Matt Wolfgang (Matt_Wolfgang@med.unc.edu)

November 2 Simon Frost, Ph.D., Univ. of CA, San Diego, TBA. Co-sponsored by CFAR. Host: Ron Swanstrom (risunc@med.unc.edu)

November 9 Salam Ibrahim, Ph.D., Assistant Professor, Food Microbiology and Biotechnology Laboratory, North Carolina A & T State University, TBA. Host: Morgan Giddings (giddings@unc.edu)

November 16 Michael Laub, Ph.D., Fellow, Harvard University, TBA. Host: Bob Bourret (bourret@med.unc.edu)

November 30 Etty (Tika) Benveniste, Ph.D., Professor and Chair, Univ. of Alabama at Birmingham, "Regulation of CD40 Expression in Macrophages/Microglia: Inhibition by SOCS-1 and SOCS-3." Host: Jenny Ting (jenny_ting@med.unc.edu)

For more seminar information visit http://microimm.med.unc.edu/calendar.aspx

Conferences of Interest

People's Schedules

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